R&D ITEM

Ama Filler

NO.
Product Name 
Feature & Ues 
01
Beffi - Dew Specia I
(Implant Type)

Nose
02
Beffi - Dew Specia V 
(Volum Type)

Nasolabial Fold
03
Beffi - Dew Beauty 
Eye & Lip Fine 
/ Wrinkles
04
Beffi - Dew Star
Gorgeous Glow
05
Beffi - Dew Happy
Urology
( Corium · Vagina)
  
06
Beffi - Dew Secret
Urology
( Glans · Vagina)

07
Beffi - Dew Befull Hair 
Hair 

R&D ITEM


Ama Filler

NO.

Product Name

Feature & Ues
01

Beffi - Dew Specia I (Implant Type)

Nose
02
Beffi - Dew Specia V (Volum Type)
Nasolabial Fold
03
Beffi - Dew Beauty
Eye & Lip Fine / Wrinkles
04Beffi - Dew Star
Gorgeous Glow
05Beffi - Dew Happy

Urology( Corium / Vagina)

)06Beffi - Dew Secret

Urology( Glans / Vagina)

07Beffi - Dew Befull Hair
Hair

Reserch Article - Adv. Mater. Technol. 2022, 2201478 :

High Molecular Weight Fucoidan Loading Into and Release from Hyaluronate-Based Prefabricated Hydrogel and its Nanogel Particles Controlled by Variable Pitch and Differential Extensional Shear Technology of Advanced Twin Screw-Based System 

Abstract:

Efficient incorporation of high molecular weight drug into prefabricated hydrogel and its delivery are big challenges in its applications to drug delivery and tissue regeneration using a 3D bioprinting system. In this work, a new method of loading a model high molecular weight drug (fucoidan with 200 kDa) into prefabricated hyaluronate-based terpolymeric gel is developed by using an advanced screw-based extrusion printing system. This system effectively incorporates the fucoidan biomolecules into the fabricated crosslinked gel within 60 s at significantly higher percentages without much change in gel properties. Less damage in gel network is achieved through variable pitch and differential extensional shear mechanism by optimization of bioprinting conditions. Importantly, fucoidan-loaded nanoparticles (NPs) are developed using the advanced extrusion system at high screw rpm and with increased residence time using recirculation. The encapsulation efficiency, sustained release of fucoidan, and in vitro cell culture studies confirm the nontoxic nature of the drug-loaded gels and nanogels at lower doses, exhibiting the biomedical application potentials of this advanced screw-based extrusion printing system and drug-loaded NPs formation in pharmaceuticals, 3D bioprinting, tissue engineering as well as maximal drug loading into and sustained release from prefabricated gels.